Article

Mitochondrial cytochrome <i>c</i> liberates the nucleophosmin-sequestered ARF tumor suppressor in the nucleolus

2020-05-08

Abstract excerpt

The alternative reading frame (ARF) protein is crucial in the cellular response to oncogenic stress, being likewise the second most frequently inactivated gene in a wide spectrum of human cancers. ARF is usually sequestered in the nucleolus by the well-known oncogenic nucleophosmin (NPM) protein and is liberated in response to cell damage to exhibit its tumor-suppressor ability. However, the mechanism underlying A...

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Literature Corpus work: a32a8b24-d0e4-5b31-9025-c60881d043fd
DOI: 10.1101/2020.05.07.057075

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