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Article

The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.

The Journal of biological chemistry - 10 Jun 2016

Dyer Douglas P, Salanga Catherina L, Johns Scott C, Valdambrini Elena, Fuster Mark M, Milner Caroline M, Day Anthony J, Handel Tracy M

Abstract excerpt

TNF-stimulated gene-6 (TSG-6) is a multifunctional protein secreted in response to pro-inflammatory stimuli by a wide range of cells, including neutrophils, monocytes, and endothelial cells. It has been shown to mediate anti-inflammatory and protective effects when administered in disease models, in part, by reducing neutrophil infiltration. Human TSG-6 inhibits neutrophil migration by binding CXCL8 through its...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27044744
DOI: 10.1074/jbc.M116.720953
PMCID: PMC4933465

Genes

CCL5
CXCL8
CCL19
CCL2
CCL21
CCL27
CCL7
CXCL11
CXCL12
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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