Article
The variant landscape and function of DDX3X in cancer and neurodevelopmental disorders.
Trends in molecular medicine - 1 Sept 2023
Gadek Margaret, Sherr Elliott H, Floor Stephen N
Abstract excerpt
RNA molecules rely on proteins across their life cycle. DDX3X encodes an X-linked DEAD-box RNA helicase with a Y-linked paralog, DDX3Y. DDX3X is central to the RNA life cycle and is implicated in many conditions, including cancer and the neurodevelopmental disorder DDX3X syndrome. DDX3X-linked conditions often exhibit sex differences, possibly due to differences between expression or function of the X- and...
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