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Article

Mapping heterogeneity in patient-derived melanoma cultures by single-cell RNA-seq.

Oncotarget - 3 Jan 2017

Gerber Tobias, Willscher Edith, Loeffler-Wirth Henry, Hopp Lydia, Schadendorf Dirk, Schartl Manfred, Anderegg Ulf, Camp Gray, Treutlein Barbara, Binder Hans, Kunz Manfred

Abstract excerpt

Recent technological advances in single-cell genomics make it possible to analyze cellular heterogeneity of tumor samples. Here, we applied single-cell RNA-seq to measure the transcriptomes of 307 single cells cultured from three biopsies of three different patients with a BRAF/NRAS wild type, BRAF mutant/NRAS wild type and BRAF wild type/NRAS mutant melanoma metastasis, respectively. Analysis based on...

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Source

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Identifiers

PMID: 27903987
DOI: 10.18632/oncotarget.13666
PMCID: PMC5352202

Genes

BRAF
NRAS
CDK4
ABCB5
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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