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Article

Spatially Resolved Transcriptomics Enables Dissection of Genetic Heterogeneity in Stage III Cutaneous Malignant Melanoma.

Cancer research - 15 Oct 2018

Thrane Kim, Eriksson Hanna, Maaskola Jonas, Hansson Johan, Lundeberg Joakim

Abstract excerpt

Cutaneous malignant melanoma (melanoma) is characterized by a high mutational load, extensive intertumoral and intratumoral genetic heterogeneity, and complex tumor microenvironment (TME) interactions. Further insights into the mechanisms underlying melanoma are crucial for understanding tumor progression and responses to treatment. Here we adapted the technology of spatial transcriptomics (ST) to melanoma lymph...

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PMID: 30154148
DOI: 10.1158/0008-5472.CAN-18-0747

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