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Article

MITF-High and MITF-Low Cells and a Novel Subpopulation Expressing Genes of Both Cell States Contribute to Intra- and Intertumoral Heterogeneity of Primary Melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2017

Ennen Marie, Keime Céline, Gambi Giovanni, Kieny Alice, Coassolo Sebastien, Thibault-Carpentier Christelle, Margerin-Schaller Fanny, Davidson Guillaume, Vagne Constance, Lipsker Dan, Davidson Irwin

Abstract excerpt

Purpose: Understanding tumor heterogeneity is an important challenge in current cancer research. Transcription and epigenetic profiling of cultured melanoma cells have defined at least two distinct cell phenotypes characterized by distinctive gene expression signatures associated with high or low/absent expression of microphthalmia-associated transcription factor (MITF). Nevertheless, heterogeneity of cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Share to Microphthalmia-Associated Transcription Factor

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Source

Identifiers

PMID: 28855355
DOI: 10.1158/1078-0432.CCR-17-0010

Genes

MITF
PAX3
SOX10
ZEB2

Provenance

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