Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer

30 Nov 2016

Abstract excerpt

Abstract Purpose: Constitutively active WNT signaling is a hallmark of colorectal cancers and a driver of malignant tumor progression. Therapeutic targeting of WNT signaling is difficult due to high pathway complexity and its role in tissue homeostasis. Here, we identify the transcription factor ADNP as a pharmacologically inducible repressor of WNT signaling in colon cancer. Experimental Design: We used...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer, Stress, Anesthesia, and Immune Response
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27903678
DOI: 10.1158/1078-0432.ccr-16-1604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal CancerPMID 27903678Read ↗

Disrupting ß-catenin dependent Wnt signaling activates an invasive gene program predictive of colon cancer progressionSemantic proximity Read ↗

Disruption of β-Catenin–Dependent Wnt Signaling in Colon Cancer Cells Remodels the Microenvironment to Promote Tumor InvasionSemantic proximity Read ↗

Targeting the NOTCH2/ADAM10/TCF7L2 Axis‐Mediated Transcriptional Regulation of Wnt Pathway Suppresses Tumor Growth and Enhances Chemosensitivity in Colorectal CancerSemantic proximity Read ↗

Wnt-11 as a Potential Prognostic Biomarker and Therapeutic Target in Colorectal CancerSemantic proximity Read ↗

XPO1 inhibition modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesisSemantic proximity Read ↗

Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations.Semantic proximity Read ↗

Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer.Semantic proximity Read ↗

Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer.Semantic proximity Read ↗

Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.Semantic proximity Read ↗

Oncogenic beta-catenin and MMP-7 (matrilysin) cosegregate in late-stage clinical colon cancer.Semantic proximity Read ↗

The Transcriptional Repressor SNAIL Is Overexpressed in Human Colon CancerSemantic proximity Read ↗

Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.