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Article

Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity

27 Jun 2012

Abstract excerpt

Aberrant activation of canonical Wingless-type MMTV integration site family (Wnt) signaling is pathognomonic of colorectal cancers (CRC) harboring functional mutations in either adenomatous polyposis coli or β-catenin. Coincident with Wnt cascade activation, CRCs also up-regulate the expression of Wnt pathway feedback inhibitors, particularly the putative tumor suppressor, Axin2. Because Axin2 serves as a...

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PMID: 22745173
DOI: 10.1073/pnas.1203015109

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Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activityPMID 22745173Read ↗

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