Article
Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer.
Oncotarget - 29 Sept 2015
Heerma van Voss Marise R, Vesuna Farhad, Trumpi Kari, Brilliant Justin, Berlinicke Cynthia, de Leng Wendy, Kranenburg Onno, Offerhaus G Johan, Bürger Horst, van der Wall Elsken, van Diest Paul J, Raman Venu
Abstract excerpt
Identifying druggable targets in the Wnt-signaling pathway can optimize colorectal cancer treatment. Recent studies have identified a member of the RNA helicase family DDX3 (DDX3X) as a multilevel activator of Wnt signaling in cells without activating mutations in the Wnt-signaling pathway. In this study, we evaluated whether DDX3 plays a role in the constitutively active Wnt pathway that drives colorectal...
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