Article

XPO1 inhibition modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> Colorectal Cancer (CRC) is the second leading cause of cancer-related death in the U.S. and high-risk individuals face a notably higher likelihood of developing CRC based on their genetic background. Hence, there is a compelling need for innovative chemopreventive treatments aimed at minimizing CRC tumorigenesis. Exportin 1 (XPO1; also referred to as CRM1) plays a pivotal role in transporting pr...

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Literature Corpus work: 96172b47-3feb-59b5-b6fa-42851533990b
DOI: 10.1101/2024.10.31.621312

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