Article
Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer.
International journal of cancer - 15 Oct 2007
Rohde Franziska, Rimkus Caroline, Friederichs Jan, Rosenberg Robert, Marthen Carmen, Doll Dietrich, Holzmann Bernhard, Siewert Jörg-Rüdiger, Janssen Klaus-Peter
Abstract excerpt
Osteopontin (OPN) is a secreted phosphoprotein, which has been reported to be associated with tumor progression in numerous solid tumors. In a previous transcriptome study on colorectal cancer, we identified the gene OPN among the most strongly up-regulated transcripts. OPN has been suggested as a putative target of Wnt signaling, but the molecular mechanism responsible for its aberrant transcription is not fully...
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