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Article

Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.

Cancer research - 15 Jun 2011

Osada Takuya, Chen Minyong, Yang Xiao Yi, Spasojevic Ivan, Vandeusen Jeffrey B, Hsu David, Clary Bryan M, Clay Timothy M, Chen Wei, Morse Michael A, Lyerly H Kim

Abstract excerpt

Wnt/β-catenin pathway activation caused by adenomatous polyposis coli (APC) mutations occurs in approximately 80% of sporadic colorectal cancers (CRC). The antihelminth compound niclosamide downregulates components of the Wnt pathway, specifically Dishevelled-2 (Dvl2) expression, resulting in diminished downstream β-catenin signaling. In this study, we determined whether niclosamide could inhibit the...

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Identifiers

PMID: 21531761
DOI: 10.1158/0008-5472.CAN-10-3978
PMCID: PMC3117125

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APC

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