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Article

The pro-fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride-induced experimental liver injury.

Immunology and cell biology - 1 May 2017

Wang Xin M, Holz Lauren E, Chowdhury Sumaiya, Cordoba Shaun P, Evans Kathryn A, Gall Margaret G, Vieira de Ribeiro Ana Júlia, Zheng Yuan Zhou, Levy Miriam T, Yu Denise Mt, Yao Tsun-Wen, Polak Natasa, Jolly Christopher J, Bertolino Patrick, McCaughan Geoffrey W, Gorrell Mark D

Abstract excerpt

Liver fibrosis is a progressive pathological process involving inflammation and extracellular matrix deposition. Dipeptidyl peptidase 4 (DPP4), also known as CD26, is a cell surface glycoprotein and serine protease. DPP4 binds to fibronectin, can inactivate specific chemokines, incretin hormone and neuropeptides, and influences cell adhesion and migration. Such properties suggest a pro-fibrotic role for this...

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Identifiers

PMID: 27899813
DOI: 10.1038/icb.2016.116

Genes

DPP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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