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Article

Splenic B Cells Accumulate and Adopt a Pro-Inflammatory Phenotype to Accelerate Fibrosis in a CCl4-Induced Liver Fibrosis Model.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 31 Jul 2026

Feng Keping, Fei Qiaoman, Zhang Chongyu, Feng Junqiao, Du Ke, Huang Na, Zhang Xurui, Zhou Zhe, Zhang Chengbo, Zhang Shaoying, Lu Shemin, Dong Yanying, Kong Guangyao

Abstract excerpt

The spleen plays a significant role in hepatic fibrosis progression. B cells are the main splenic lymphocytes, but their specific contributions and underlying mechanisms remain unclear. Hepatic fibrosis was induced in mice by intraperitoneal administration of carbon tetrachloride (CCl4). Splenectomy or sham operation was performed during the fibrotic process. Hepatic fibrosis severity and the proportion of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42485008
DOI: 10.1096/fj.202601010R
PMCID: PMC13390712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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