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Article

Effect of organic anion-transporting polypeptide 1B1 (OATP1B1) polymorphism on the single- and multiple-dose pharmacokinetics of enalapril in healthy Chinese adult men.

Clinical therapeutics - 1 May 2011

Tian Lei, Liu Hong, Xie Shuang, Jiang Juanjuan, Han Lulu, Huang Yiling, Li Yishi

Abstract excerpt

BACKGROUND: Enalapril is an angiotensin-converting enzyme (ACE) inhibitor approved for the treatment of mild to severe hypertension and congestive heart failure. There is evidence that enalapril may be an organic anion-transporting polypeptide 1B1 (OATP1B1) substrate, suggesting that genetic polymorphisms of the OATP1B1 gene may play a role in causing the interindividual pharmacokinetic differences of this drug....

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Identifiers

PMID: 21665049
DOI: 10.1016/j.clinthera.2011.04.018

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ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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