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Article

Pharmacogenetics of dabigatran etexilate interindividual variability.

Thrombosis research - 1 Aug 2016

Dimatteo Claudia, D'Andrea Giovanna, Vecchione Gennaro, Paoletti Oriana, Cappucci Filomena, Tiscia Giovanni Luca, Buono Matteo, Grandone Elvira, Testa Sophie, Margaglione Maurizio

Abstract excerpt

INTRODUCTION: Dabigatran etexilate is given in fixed doses without coagulation monitoring for the prevention of blood clots in at risk adults. A high inter-individual variability in blood concentrations of the active metabolite of dabigatran has been reported. ABCB1 and CES1 exert an important effect in the metabolism of dabigatran etexilate and allele variants at these two loci are likely to play a pivotal role....

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Source

Identifiers

PMID: 27261537
DOI: 10.1016/j.thromres.2016.05.025

Genes

CES1
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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