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Article

Functional exploration of colorectal cancer genomes using Drosophila.

Nature communications - 29 Nov 2016

Bangi Erdem, Murgia Claudio, Teague Alexander G S, Sansom Owen J, Cagan Ross L

Abstract excerpt

The multigenic nature of human tumours presents a fundamental challenge for cancer drug discovery. Here we use Drosophila to generate 32 multigenic models of colon cancer using patient data from The Cancer Genome Atlas. These models recapitulate key features of human cancer, often as emergent properties of multigenic combinations. Multigenic models such as ras p53 pten apc exhibit emergent resistance to a panel...

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Identifiers

PMID: 27897178
DOI: 10.1038/ncomms13615
PMCID: PMC5141297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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