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Article

Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice.

The Journal of nutritional biochemistry - 1 Aug 2016

Pinçon Anthony, Coulombe Jean-Denis, Chouinard-Watkins Raphaël, Plourde Mélanie

Abstract excerpt

Carrying at least one apolipoprotein E ε4 allele (E4+) is the main genetic risk factor for Alzheimer's disease (AD). Epidemiological studies support that consuming fatty fish rich in docosahexaenoic acid (DHA; 22:6ω3) is protective against development of AD. However, this protective effect seems not to hold in E4+. The involvement of APOE genotype on the relationship between DHA intake and cognitive decline could...

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Source

Identifiers

PMID: 27239755
DOI: 10.1016/j.jnutbio.2016.05.001

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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