Article
Identification of different ALK mutations in a pair of neuroblastoma cell lines established at diagnosis and relapse.
Oncotarget - 27 Dec 2016
Chen Lindi, Humphreys Angharad, Turnbull Lisa, Bellini Angela, Schleiermacher Gudrun, Salwen Helen, Cohn Susan L, Bown Nick, Tweddle Deborah A
Abstract excerpt
Anaplastic Lymphoma Kinase (ALK) is a transmembrane receptor kinase that belongs to the insulin receptor superfamily and has previously been shown to play a role in cell proliferation, migration and invasion in neuroblastoma. Activating ALK mutations are reported in both hereditary and sporadic neuroblastoma tumours, and several ALK inhibitors are currently under clinical evaluation as novel treatments for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.