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[A distinctive scheme of amino acid replacement was evolved for the generation of diversity, among hypervariable positions (author's transl)].

Annales d'immunologie - 1 Jan 2000

Bourgarit J J

Abstract excerpt

The diversity of amino acid residues, at a same position when comparing several aligned polypeptide sequences, may be translated as follows. The way along which a given amino acid, A, is replaced--in average--by another amino acid, B, is characterized by a coefficient linked with the pair A-B. Thus, one given amino acid is given a "set" of 19 coefficients, and the 20 different such sets may be analyzed. This...

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PMID: 6784660

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