Article
Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains.
Molecular neurodegeneration - 25 Nov 2016
Ma Li, Allen Mariet, Sakae Nobutaka, Ertekin-Taner Nilufer, Graff-Radford Neill R, Dickson Dennis W, Younkin Steven G, Sevlever Daniel
Abstract excerpt
BACKGROUND: Genetic analyses showed that the triggering receptor expressed in myeloid cells 2 (TREM2) p.R47H variant increases the risk for Alzheimer's disease (AD). The question of whether the p.R47H mutation affects expression or function of the receptor remains unanswered. To address this question we quantified mRNA and analyzed protein profiles of WT and p.R47H TREM2 in human brains. METHODS: Quantitative...
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