Article
Association of Single-Nucleotide Polymorhism C3435T in the ABCB1 Gene with Opioid Sensitivity in Treatment of Postoperative Pain.
Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) - 1 Nov 2016
Dzambazovska-Trajkovska Vanja, Nojkov Jordan, Kartalov Andrijan, Kuzmanovska Biljana, Spiroska Tatjana, Seljmani Redzep, Trajkovski Gjorgji, Matevska-Geshkovska Nadica, Dimovski Aleksandar
Abstract excerpt
BACKGROUND: The minimal effective analgesic concentration of opioids required for satisfactory analgesia may differ significantly among the patients. Genetic factors may contribute to the variable response to opioids by affecting their pharmacokinetics or pharmacodynamics. METHODS: Ninety nine patients undergoing abdominal surgery with colorectal anastomosis because of colorectal carcinoma were enrolled in the...
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