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Article

Experimental Evaluation of ABCB1 C3435T (rs1045642) Gene Polymorphism and Its Association with Postoperative Analgesia in Hip Replacement Surgery.

Journal of visualized experiments : JoVE - 9 Jan 2026

Wu Shuiliang, Fu Jing, Xie Chaochun, Chen Xi

Abstract excerpt

This study investigated the association between the ABCB1 (MDR1) C3435T (rs1045642) gene polymorphism and postoperative analgesia in patients undergoing hip replacement surgery. A total of 100 patients who underwent hip replacement in our hospital between January 2023 and January 2024 received postoperative patient-controlled intravenous analgesia with sufentanil. Preoperative serum samples were collected, and...

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Aged
Analgesics, Opioid
Arthroplasty, Replacement, Hip
ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 41587133
DOI: 10.3791/69549

Genes

ABCB1

Variants

rs1045642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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