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Article

Environmental and genetic factors associated with morphine response in the postoperative period.

Clinical pharmacology and therapeutics - 1 Apr 2006

Coulbault Laurent, Beaussier Marc, Verstuyft Céline, Weickmans Henri, Dubert Liliane, Trégouet David, Descot Christelle, Parc Yann, Lienhart André, Jaillon Patrice, Becquemont Laurent

Abstract excerpt

OBJECTIVE: The aim of this study was to investigate the respective influence of genetic and nongenetic factors on morphine dose requirements and adverse effects after colorectal surgery. METHODS: Seventy-four patients who planned to undergo colorectal surgery were included in this pilot study. The cumulative 24-hour postoperative dose of morphine and postoperative nausea or vomiting requiring the antiemetic...

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Topics

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Share to Analgesics, Opioid
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucuronosyltransferase

Share to Morphine

Share to Pain Measurement

Share to Pain, Postoperative

Share to Postoperative Period

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 16580900
DOI: 10.1016/j.clpt.2006.01.007

Genes

ABCB1
OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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