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Article

Glucokinase (GCK) in diabetes: from molecular mechanisms to disease pathogenesis.

Cellular & molecular biology letters - 8 Sept 2024

Abu Aqel Yasmin, Alnesf Aldana, Aigha Idil I, Islam Zeyaul, Kolatkar Prasanna R, Teo Adrian, Abdelalim Essam M

Abstract excerpt

Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver. Mutations in the GCK gene have been associated with various monogenic diabetes (MD) disorders, including permanent neonatal diabetes mellitus (PNDM) and maturity-onset diabetes of the young (MODY), highlighting its importance in...

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Identifiers

PMID: 39245718
DOI: 10.1186/s11658-024-00640-3
PMCID: PMC11382428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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