Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia.

doi:10.1074/jbc.M111751200

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Article

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia.

The Journal of biological chemistry - 29 Mar 2002

Laybutt D Ross, Sharma Arun, Sgroi Dennis C, Gaudet Justin, Bonner-Weir Susan, Weir Gordon C

Abstract excerpt

In models of type 2 diabetes the expression of beta-cell genes is altered, but these changes have not fully explained the impairment in beta-cell function. We hypothesized that changes in beta-cell phenotype and global alterations in both carbohydrate and lipid pathways are likely to contribute to secretory abnormalities. Therefore, expression of genes involved in carbohydrate and lipid metabolism were analyzed...

Topics

Adenosine Triphosphate
Animals
Base Sequence
DNA Primers
Gene Expression Profiling
Glucose
Hyperglycemia
Insulin
Insulin Secretion
Islets of Langerhans
Male
Phenotype
Polymerase Chain Reaction
RNA, Messenger
Rats
Rats, Sprague-Dawley

Source

Open in PubMed

Identifiers

PMID: 11782487
DOI: 10.1074/jbc.M111751200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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