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Article

Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1.

Stem cell research - 1 Sept 2016

Pires Carlota, Schmid Benjamin, Petræus Carina, Poon Anna, Nimsanor Natakarn, Nielsen Troels T, Waldemar Gunhild, Hjermind Lena E, Nielsen Jørgen E, Hyttel Poul, Freude Kristine K

Abstract excerpt

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease causing neural cell degeneration and brain atrophy and is considered to be the most common form of dementia. We previously generated an induced pluripotent stem cell (iPSC) line from an AD patient carrying an A79V mutation in PSEN1 as an in vitro disease model. Here we generated a gene-corrected version from this hiPSC line by...

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Source

Identifiers

PMID: 27879212
DOI: 10.1016/j.scr.2016.08.002

Genes

PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1.PMID 27879212Read ↗

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