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Generation of isogenic control DJ-1-delP GC13 for the genetic Parkinson's disease-patient derived iPSC line DJ-1-delP (LCSBi008-A-1).

Stem cell research - 1 Jul 2022

Mencke Pauline, Hanss Zoé, Jarazo Javier, Massart François, Rybicki Arkadiusz, Petkovski Elizabet, Glaab Enrico, Boussaad Ibrahim, Bonifati Vincenzo, Christian Schwamborn Jens, Mandemakers Wim, Krüger Rejko

Abstract excerpt

We describe the generation of an isogenic control cell line DJ-1-delP GC13 from an induced pluripotent stem cell (iPSC) line DJ-1-delP LCSBi008-A that was derived from fibroblasts obtained from a Parkinson's disease (PD) patient. Using CRISPR/Cas9 technology, we corrected the disease causing c.471_473delGCC homozygous mutation in the PARK7 gene leading to p.158P deletion in the encoded protein DJ-1. The generated...

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PMID: 35617842
DOI: 10.1016/j.scr.2022.102815

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