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Article

AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration: a prospective laboratory and patient study.

Journal of translational medicine - 21 Nov 2016

Rump Katharina, Unterberg Matthias, Bergmann Lars, Bankfalvi Agnes, Menon Anil, Schäfer Simon, Scherag André, Bazzi Zainab, Siffert Winfried, Peters Jürgen, Adamzik Michael

Abstract excerpt

BACKGROUND: The C-allele of the aquaporin (AQP5) -1364A/C polymorphism is associated with decreased AQP5 expression but increased 30-day survival in patients with severe sepsis. AQP5 expression might affect survival via an impact on cell migration. Consequently, we tested the hypothesis that (1) Aqp5 knockout (KO) compared to wild type (WT) mice show an increased survival following lipopolysaccharide (LPS)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27871297
DOI: 10.1186/s12967-016-1079-2
PMCID: PMC5117689

Genes

AQP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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