Article
The chemokine receptor 5 Delta32 mutation is associated with increased renal survival in patients with IgA nephropathy.
Kidney international - 1 Jan 2005
Panzer Ulf, Schneider André, Steinmetz Oliver M, Wenzel Ulrich, Barth Petra, Reinking Rüdiger, Becker Jan U, Harendza Sigrid, Zahner Gunther, Fischereder Michael, Krämer Bernhard K, Krämer Bernhard H, Schlöndorff Detlef, Ostendorf Tammo, Floege Jürgen, Helmchen Udo, Stahl Rolf A K
Abstract excerpt
BACKGROUND: Chemokine receptor 5 (CCR5) plays an important role in the recruitment of monocytes and T cells in inflammation and experimental studies suggest that CCR5 might be involved in the pathogenesis of IgA nephropathy. A mutation in the CCR5 gene (CCR5 Delta32), leading to a nonfunctional receptor, was recently described. We therefore evaluated the potential role of this mutation on renal survival in...
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