A Polymorphism of Bactericidal/Permeability-Increasing Protein Affects Its Neutralization Efficiency towards Lipopolysaccharide.

doi:10.3390/ijms23031324

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Article

A Polymorphism of Bactericidal/Permeability-Increasing Protein Affects Its Neutralization Efficiency towards Lipopolysaccharide.

International journal of molecular sciences - 25 Jan 2022

Ederer Katharina U, Holzinger Jonas M, Maier Katharina T, Zeller Lisa, Werner Maren, Toelge Martina, Gessner André, Bülow Sigrid

Abstract excerpt

Gram-negative sepsis driven by lipopolysaccharide (LPS) has detrimental outcomes, especially in neonates. The neutrophil-derived bactericidal/permeability-increasing protein (BPI) potently neutralizes LPS. Interestingly, polymorphism of the BPI gene at position 645 (rs4358188) corresponds to a favorable survival rate of these patients in the presence of at least one allele 645 A as opposed to 645 G. When we...

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PMID: 35163248
DOI: 10.3390/ijms23031324
PMCID: PMC8836039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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