Article
Aquaporin 5 gene promoter--1364A/C polymorphism associated with 30-day survival in severe sepsis.
Anesthesiology - 1 Apr 2011
Adamzik Michael, Frey Ulrich H, Möhlenkamp Stephan, Scherag André, Waydhas Christian, Marggraf Günther, Dammann Marc, Steinmann Jörg, Siffert Winfried, Peters Jürgen
Abstract excerpt
BACKGROUND: Because the aquaporin (AQP) 5 promoter -1364A/C polymorphism is associated with altered AQP5 expression, this association could have an impact on key mechanisms in sepsis, such as cell migration, activity of the rennin-angiotensin- aldosterone system (RAAS), and water transport across biologic membranes. Therefore, we tested the hypothesis that the AQP5 promoter -1364A/C polymorphism is associated...
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