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DNA methylation of a NF-κB binding site in the aquaporin 5 promoter impacts on mortality in sepsis

6 Dec 2019

Abstract excerpt

Abstract Altered aquaporin 5 ( AQP5 ) expression in immune cells impacts on key mechanisms of inflammation and is associated with sepsis survival. Since epigenetic regulation via DNA methylation might contribute to a differential AQP5 expression in sepsis, we tested the hypotheses that DNA methylation of the AQP5 promotor (1) influences AQP5 expression, (2) is associated with the 30-day survival of septic...

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PMID: 31811204
DOI: 10.1038/s41598-019-55051-8

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