Article
Intron Lariat RNA Inhibits MicroRNA Biogenesis by Sequestering the Dicing Complex in Arabidopsis.
PLoS genetics - 1 Nov 2016
Li Ziwei, Wang Shengpeng, Cheng Jinping, Su Chuanbin, Zhong Songxiao, Liu Qi, Fang Yuda, Yu Yao, Lv Hong, Zheng Yun, Zheng Binglian
Abstract excerpt
Lariat RNAs formed as by-products of splicing are quickly degraded by the RNA debranching enzyme 1 (DBR1), leading to their turnover. Null dbr1 mutants in both animals and plants are embryo lethal, but the mechanism underlying the lethality remains unclear. Here we characterized a weak mutant allele of DBR1 in Arabidopsis, dbr1-2, and showed that a global increase in lariat RNAs was unexpectedly accompanied by a...
Topics
- Alleles
- Arabidopsis
- Arabidopsis Proteins
- Cell Cycle Proteins
- Gene Expression Regulation, Plant
- Introns
- MicroRNAs
- Mutant Proteins
- RNA Nucleotidyltransferases
- RNA Processing, Post-Transcriptional
- RNA Splicing
- RNA-Binding Proteins
- Ribonuclease III