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Article

The nuclear dsRNA binding protein HYL1 is required for microRNA accumulation and plant development, but not posttranscriptional transgene silencing.

Current biology : CB - 17 Feb 2004

Vazquez Franck, Gasciolli Virginie, Crété Patrice, Vaucheret Hervé

Abstract excerpt

MicroRNAs (miRNAs) are 21-24 nucleotides long molecules processed from imperfect double-stranded RNAs (dsRNAs). They regulate gene expression by targeting complementary mRNA for cleavage or interfering with their translation. In Arabidopsis, point mutations in or short truncations of the nuclear DICER-LIKE1 (DCL1) or HEN1 protein reduce miRNA accumulation and increase uncleaved target mRNAs accumulation,...

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Identifiers

PMID: 14972688
DOI: 10.1016/j.cub.2004.01.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The nuclear dsRNA binding protein HYL1 is required for microRNA accumulation and plant development, but not posttranscriptional transgene silencing.PMID 14972688Read ↗

The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation.Semantic proximity Read ↗

A dominant mutation in DCL1 suppresses the hyl1 mutant phenotype by promoting the processing of miRNA.Semantic proximity Read ↗

The helicase and RNaseIIIa domains of Arabidopsis Dicer-Like1 modulate catalytic parameters during microRNA biogenesis.Semantic proximity Read ↗

Arabidopsis primary microRNA processing proteins HYL1 and DCL1 define a nuclear body distinct from the Cajal body.Semantic proximity Read ↗

The N-terminal double-stranded RNA binding domains of Arabidopsis HYPONASTIC LEAVES1 are sufficient for pre-microRNA processing.Semantic proximity Read ↗

Transcriptome analyses revealed diverse expression changes in ago1 and hyl1 Arabidopsis mutants.Semantic proximity Read ↗

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Ectopic DICER-LIKE1 expression in P1/HC-Pro Arabidopsis rescues phenotypic anomalies but not defects in microRNA and silencing pathways.Semantic proximity Read ↗

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