Article
A dominant mutation in DCL1 suppresses the hyl1 mutant phenotype by promoting the processing of miRNA.
RNA (New York, N.Y.) - 1 Mar 2009
Tagami Yuko, Motose Hiroyasu, Watanabe Yuichiro
Abstract excerpt
MicroRNAs (miRNAs) are sequence-specific negative regulators of gene expression generated by DICER-LIKE1 (DCL1) with the assistance of a double-stranded RNA-binding protein, HYPONASTIC LEAVES1 (HYL1), in Arabidopsis. To achieve a better understanding of miRNA biogenesis, we isolated hyl1 suppressors. Our genetic screening identified a novel semidominant mutation in DCL1 (dcl1-13), which causes an amino acid...
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