Article
mRNA Decay of Most Arabidopsis miRNA Targets Requires Slicer Activity of AGO1.
Plant physiology - 1 Aug 2016
Arribas-Hernández Laura, Kielpinski Lukasz Jan, Brodersen Peter
Abstract excerpt
MicroRNAs (miRNAs) are key posttranscriptional regulators of gene expression in animals and plants. They guide RNA-induced silencing complexes to complementary target mRNA, thereby mediating mRNA degradation or translational repression. ARGONAUTE (AGO) proteins bind directly to miRNAs and may catalyze cleavage (slicing) of target mRNAs. In animals, miRNA target degradation via slicing occurs only exceptionally,...
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