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Article

Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation.

Nature cell biology - 1 Dec 2016

Ramkumar Nitya, Omelchenko Tatiana, Silva-Gagliardi Nancy F, McGlade C Jane, Wijnholds Jan, Anderson Kathryn V

Abstract excerpt

During gastrulation of the mouse embryo, individual cells ingress in an apparently stochastic pattern during the epithelial-to-mesenchymal transition (EMT). Here we define a critical role of the apical protein Crumbs2 (CRB2) in the gastrulation EMT. Static and live imaging show that ingressing cells in Crumbs2 mutant embryos become trapped at the primitive streak, where they continue to express the epiblast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27870829
DOI: 10.1038/ncb3442
PMCID: PMC5268168

Genes

CRB2
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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