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Article

The extracellular and intracellular regions of Crb2a play distinct roles in guiding the formation of the apical zonula adherens.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 May 2020

Lin Yuchen, Weng Kechao, Liang Jiancheng, Zhou Yao, Hao Qinlong, Hao Yumei, Yao Ke, Zou Jian

Abstract excerpt

The transmembrane protein Crumbs (Crb), a key regulator of apical polarity, has a known involvement in establishment of the apical zonula adherens in epithelia, although the precise mechanism remains elusive. The zonula adherens are required to maintain the integrity and orderly arrangement of epithelia. Loss of the zonula adherens leads to morphogenetic defects in the tissues derived from epithelium. In this...

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PMID: 32044715
DOI: 10.1016/j.biopha.2020.109942

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