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Article

T-cell stimuli independently sum to regulate an inherited clonal division fate

21 Nov 2016

Abstract excerpt

In the presence of antigen and costimulation, T cells undergo a characteristic response of expansion, cessation and contraction. Previous studies have revealed that population-level reproducibility is a consequence of multiple clones exhibiting considerable disparity in burst size, highlighting the requirement for single-cell information in understanding T-cell fate regulation. Here we show that individual T-cell...

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PMID: 27869196
DOI: 10.1038/ncomms13540

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