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Competition between T cells maintains clonal dominance during memory inflation induced by MCMV

13 Feb 2013

Abstract excerpt

Both human cytomegalovirus (HCMV) and murine cytomegalovirus (MCMV) establish persistent infections that induce the accumulation of virus-specific T cells over time in a process called memory inflation. It has been proposed that T cells expressing T-cell receptors (TCRs) with high affinity for HCMV-derived peptides are preferentially selected after acute HCMV infection. To test this in the murine model, small...

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PMID: 23404526
DOI: 10.1002/eji.201242940

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