Article
Heterogeneity in the clonal T cell response. Implications for models of T cell activation and cytokine phenotype development.
Immunologic research - 1 Jan 1998
Weaver C T, Saparov A, Kraus L A, Rogers W O, Hockett R D, Bucy R P
Abstract excerpt
The T cell can be defined in the context of two properties--the recognition specificity of the T cell receptor (TCR) heterodimer and the functional response of the T cell after TCR stimulation. Once a particular TCR heterodimer is expressed and successfully selected during thymic development, the...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- Clone Cells
- Cytokines
- Dose-Response Relationship, Immunologic
- Flow Cytometry
- Gene Expression Regulation
- Humans
- In Situ Hybridization
- Lymphocyte Activation
- Mice
- Mice, Transgenic
- Models, Immunological
- Phenotype
- Receptors, Antigen, T-Cell
- T-Lymphocytes
- Th1 Cells
- Th2 Cells