Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Weakly self-reactive T-cell clones can homeostatically expand when present at low numbers.

European journal of immunology - 1 Jan 2017

Vrisekoop Nienke, Artusa Patricio, Monteiro Joao P, Mandl Judith N

Abstract excerpt

T-cell division is central to maintaining a stable T-cell pool in adults. It also enables T-cell expansion in neonates, and after depletion by chemotherapy, bone marrow transplantation, or infection. The same signals required for T-cell survival in lymphoreplete settings, IL-7 and T-cell receptor (TCR) interactions with self-peptide MHC (pMHC), induce division when T-cell numbers are low. The strength of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmunity
Share to CD4-Positive T-Lymphocytes
Share to Clone Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocyte Count

Share to Lymphopenia

Share to Major Histocompatibility Complex

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocyte Subsets

Source

Identifiers

PMID: 27792294
DOI: 10.1002/eji.201646540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Weakly self-reactive T-cell clones can homeostatically expand when present at low numbers.PMID 27792294Read ↗

New insights on T-cell self-tolerance.Semantic proximity Read ↗

Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon.Semantic proximity Read ↗

The chronicles of T-cell exhaustionSemantic proximity Read ↗

An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.Semantic proximity Read ↗

Homeostasis of Naive and Memory T Lymphocytes.Semantic proximity Read ↗

Replenishing B lymphocytes in health and diseaseSemantic proximity Read ↗

How many TCR clonotypes does a body maintain?Semantic proximity Read ↗

Excess generation and activation of naturally arising memory-phenotype CD4+ T lymphocytes are inhibited by regulatory T cells in steady state.Semantic proximity Read ↗

Exhausted T cell phenotypes depend on TCR signal strength.Semantic proximity Read ↗

T Cell Fate at the Single-Cell LevelSemantic proximity Read ↗

Heterogeneity in the clonal T cell response. Implications for models of T cell activation and cytokine phenotype development.Semantic proximity Read ↗

The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.