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Article

How heterogeneous thymic output and homeostatic proliferation shape naive T cell receptor clone abundance distributions

2019-06-19

Abstract excerpt

The set of T cells that express the same T cell receptor (TCR) sequence represent a T cell clone. The number of different naive T cell clones in an organism reflects the number of different T cell receptors (TCRs) arising from recombination of the V(D)J gene segments during T cell development in the thymus. TCR diversity and more specifically, the clone abundance distribution is an important factor in immune funct...

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Literature Corpus work
412e75d2-9fc2-57a8-bba1-999f6450b0e2
DOI
10.1101/674937
Open publication

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