Article
DNA methylation patterns re-establish during clonal expansion restoring cell-to-cell epialleles heterogeneity.
Biology direct - 2 Jun 2026
Costabile Davide, Russo Maddalena, Della Monica Rosa, Buonaiuto Michela, De Riso Giulia, Sabbarese Marta, Catapano Giuseppe, Cocozza Sergio, Visconti Roberta, Chiariotti Lorenzo, Cuomo Mariella
Abstract excerpt
It is still debated whether the combination of methylated and unmethylated CpGs, defined as epialleles, is stably propagated during cell division or whether epiallele diversity can dynamically emerge over time. By analyzing epiallele profiles in putative single-cell-derived clones, we sought to track the behaviour of DNA methylation profiles through cell divisions to determine whether epialleles are faithfully...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.