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Article

MRLocus: Identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity.

PLoS genetics - 1 Apr 2021

Zhu Anqi, Matoba Nana, Wilson Emma P, Tapia Amanda L, Li Yun, Ibrahim Joseph G, Stein Jason L, Love Michael I

Abstract excerpt

Expression quantitative trait loci (eQTL) studies are used to understand the regulatory function of non-coding genome-wide association study (GWAS) risk loci, but colocalization alone does not demonstrate a causal relationship of gene expression affecting a trait. Evidence for mediation, that perturbation of gene expression in a given tissue or developmental context will induce a change in the downstream GWAS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33872308
DOI: 10.1371/journal.pgen.1009455
PMCID: PMC8084342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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