Article
Characterization of TG2 and TG1-TG2 double knock-out mouse epidermis.
Amino acids - 1 Mar 2017
Pitolli Consuelo, Pietroni Valentina, Marekov Lyuben, Terrinoni Alessandro, Yamanishi Kiyofumi, Mazzanti Cinzia, Melino Gerry, Candi Eleonora
Abstract excerpt
Transglutaminases (TGs) are a family of enzymes that catalyse the formation of isopeptide bonds between the γ-carboxamide groups of glutamine residues and the ε-amino groups of lysine residues leading to cross-linking reactions among proteins. Four members, TG1, TG2, TG3, and TG5, of the nine mammalian enzymes are expressed in the skin. TG1, TG3 and TG5 crosslinking properties are fundamental for cornified...
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