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Article

Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing.

Human molecular genetics - 15 Oct 2013

Amen Nicole, Mathow Daniel, Rabionet Mariona, Sandhoff Roger, Langbein Lutz, Gretz Norbert, Jäckel Carsten, Gröne Hermann-Josef, Jennemann Richard

Abstract excerpt

Skin barrier function is primarily assigned to the outer epidermal layer, the stratum corneum (SC), mainly composed of corneocytes and lipid-enriched extracellular matrix. Epidermal ceramides (Cers) are essential barrier lipids, containing ultra-long-chain (ULC) fatty acids (FAs) with a unique ω-hydroxy group, which is necessary for binding to corneocyte proteins. In the SC, Cers are believed to derive from...

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PMID: 23748427
DOI: 10.1093/hmg/ddt264

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UGCG

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