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Article

Loss of ceramide synthase 3 causes lethal skin barrier disruption

28 Oct 2011

Abstract excerpt

The stratum corneum as the outermost epidermal layer protects against exsiccation and infection. Both the underlying cornified envelope (CE) and the intercellular lipid matrix contribute essentially to these two main protective barriers. Epidermis-unique ceramides with ultra-long-chain acyl moities (ULC-Cers) are key components of extracellular lipid lamellae (ELL) and are bound to CE proteins, thereby...

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PMID: 22038835
DOI: 10.1093/hmg/ddr494

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