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Article

Keratins K2 and K10 are essential for the epidermal integrity of plantar skin.

Journal of dermatological science - 1 Jan 2016

Fischer Heinz, Langbein Lutz, Reichelt Julia, Buchberger Maria, Tschachler Erwin, Eckhart Leopold

Abstract excerpt

BACKGROUND: K1 and K2 are the main type II keratins in the suprabasal epidermis where each of them heterodimerizes with the type I keratin K10 to form intermediate filaments. In regions of the ears, tail, and soles of the mouse, only K2 is co-expressed with K10, suggesting that these keratins suffice to form a mechanically resilient cytoskeleton. OBJECTIVE: To determine the effects of the suppression of both main...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26603179
DOI: 10.1016/j.jdermsci.2015.10.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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